Cannabis Oil and Covid-19

Cannabis Oil and Covid-19 Resources

Cannabis Compounds can be Used to Prevent and Treat Covid 19 – Study

Cannabinoids – CBGA and CBDA are effective at preventing and treating COVID-19 infections. The cannabinoids do this by binding to the same receptors in humans as the SARS COVID-19 spike protein binds to. So says a brand new study from Oregon State University published in early January 2022. The study says that these two cannabinoid molecules can be used to complement vaccination as well as other currently used COVID-19 treatments.

CBGA (Cannabigerolic Acid) and CBDA (Cannabidiolic Acid) are found in every cannabis plant. They were found to be equally effective against the original COVID 19 virus and two of it’s variants – the alpha and beta variants. Both of these cannabinoid compounds have a history of being extremely safe for human use.

Cannabis Oil Covid-19

The alpha COVID variant was first detected in the United Kingdom, while the beta variant was first detected in South Africa. These two variants are of concern because they are associated with increased infection and hospitalisation numbers, as well as having a lower susceptibility to vaccination against COVID.

Researchers say that any step of the infection and replication cycle of the COVID virus is a potential target for intervention. These include cell entry, genome replication, viral maturation or viral release. However, the viral spike protein of SARS-CoV-2 binding to the human cell surface is a critical step during infection. From the article… “…cell entry inhibitors could be used to prevent SARS-CoV-2 infection as well as to shorten the course of COVID-19 infections by preventing virus particles from infecting human cells.”

Coronavirus Illustration

The study goes on to say that “…Natural products are the most successful source of drugs and drug leads in the history of pharmacology… nature continues to be a source of unique chemical structural diversity for new drug discovery…. Less than 10% of the world’s biodiversity has been evaluated for potential biological activity, so that many more useful natural lead compounds await discovery. …

As an example of a natural product with anti-SARS-CoV-2 activity, panduratin from the medicinal plant Boesenbergia rotunda was reported recently to be active against SARS-CoV-2 at both pre-entry and postinfection phases…”

The researchers used a technique called MagMASS (Magnetic Microbead Affinity Selection Screening) to screen cannabis compounds and confirmed that CBDA and CBGA blocked infection of human epithelial cells by the original live SARS-CoV-2 virus and it’s alpha and beta variants.

The table below shows which cannabinoids were tested as well as how each of them scored on the ability to bind the the human ACE2 receptor (a lower score is better):

Cannabinoidb
UHPLC retention time (min)
Cannabigerolic acid (CBGA)
3.8
Tetrahydrocannabinolic acid (THCA-A)
8.2
Cannabidiolic acid (CBDA)
3.7
Cannabinolic acid (CBNA)
6.5
Cannabigerol (CBG)
4.1
Cannabinol (CBN)
5.7
Δ8-Tetrahydrocannabinol (Δ8-THC)
6.8
Δ9-Tetrahydrocannabinol (Δ9-THC)
6.8
Cannabidiol (CBD)
4.2
Cannabichromene (CBC)
8.1
Cannabidivarin (CBDV)
3